2010 Fiscal Year Final Research Report
Epigenetic regulation of VEGF-C/-D in cervical lymph node metastasis.
| Project/Area Number |
21791967
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHINOHARA Fumiaki Tohoku University, 病院, 助教 (80400258)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔外科学一般(含病態検査学) |
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| Research Abstract |
In this study, we used the novel DNA methyltransferase inhibitor zebularine (Zeb) to investigate epigenetic influences on the secretion of VEGF-A in the OSCC cell line HSC-3. Our study revealed that neither the PI3K/Akt nor the p53 signaling pathway is required for Zeb-induced hypoxia-inducible factor-1α (HIF-1α) degradation.
In addition, we investigated the effects of EGFR antagonist Cetuximab on apoptosis induced by anti-cancer drug(5-FU or CDDP )in HSC-3 cells. In this study, we found that Cetuximab significantly enhanced the apoptosis of HSC-3 or HSC-4 cells treated by 5-FU, but not CDDP. These results suggested the mechanism depends on the PI3K/Akt signaling pathway.
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Research Products
(5 results)
