2010 Fiscal Year Final Research Report

Lidocaine iontophoresis using alternating current Development of the device for patient controlled analgesia-

Research Project

Project/Area Number	21791979
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	ANDO Shizuka Tokyo Medical and Dental University, 歯学部附属病院, 医員 (20516306)
Co-Investigator(Kenkyū-buntansha)	UMINO Masahiro TTI, エルビュー株式会社 (90014125) FUKAYAMA Haruhisa 東京医科歯科大学, 歯学部附属病院, 教授 WAKITA Ryo 東京医科歯科大学, 歯学部附属病院, 助教 (60376712)
Project Period (FY)	2009 – 2010
Keywords	イオントフォレーシス / 交流通電 / 矩形波 / 浸透効率
Research Abstract	Transdermal iontophoresis has been used for both local and systemic drug delivery. The iontophoresis of anesthetics and analgesics is used for the management of postoperative pain or cancer pain. However, some adverse effects, including electrical burns or erythema as a result of electrode polarization during electrolysis, have been reported in clinical situations. We examined the conditions of the electricity which transport lidocaine efficiently and reduce the side effects. Our purpose is to develop the transdermal patient controlled analgesia system.

(3 results)