2010 Fiscal Year Final Research Report
The role of Hemokinin-1 in neuropathic pain
| Project/Area Number |
21791980
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MATSUMURA Tomoka Tokyo Medical and Dental University, 歯学部附属病院, 医員 (40527066)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯科麻酔学 / タキキニン / ヘモキニン-1 / ミクログリア / 神経因性疼痛 |
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| Research Abstract |
We investigated the role of hemokinin-1 (HK-1), a new member of the tachykinin family, in neuropathic pain. HK-1 is encoded TAC4 gene. In the present study, TAC4 mRNA expression was increased in the cultured microgrial cells which were activated by LPS. That suggests a specific contribution of HK-1 to neuropathic pain.
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