Suppressive effect of invasion and metastasis of oral squamous cell carcinoma by maspin expression

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791982
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kanazawa University
• Principal Investigator: YOSHIZAWA Kunio 金沢大学, 附属病院, 医員 (60452108)
• Project Period (FY): 2009 – 2011
• Keywords: Maspin / がん浸潤様式 / uPA / uPAR

Research Abstract

Maspin expression in oral squamous cell carcinoma(OSCC) was detected in 64.8%. Patients with positive maspin expression had a significantly better prognosis. In contrast, maspin expression was lower in mode of invasion(Yamamoto-Kohama Critria) 4D type with high invasive potential. Moreover, Maspin expression showed a negative correlation with uPA/uPAR expression in the uPA/uPAR system. Expression pattern, uPA(+)/uPAR(+)/Maspin(-), exhibited a stronger invasive potential and the worst survival rate than other invasive grades of OSCC.

Research Products

• [Journal Article] Expression of urokinaze-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma : Association with mode of invasion and clinicopathological factors (2011)
  • Author(s): Yoshizawa K, Nozaki S, Kitahara H, Kato K, Noguchi N, Kawashiri S, Yamamoto E
  • Journal Title: Oncology Reports Volume: 26 Pages: 1555-60
  • DOI: Doi:10.3892/or.2011.1419.
  • Peer Reviewed
• [Journal Article] Expression form of p53 and PCNA at the invasive front in oral squamous cell carcinoma : correlation with clinicopathological features and prognosis (2011)
  • Author(s): Kato K, Kawashiri S, Yoshizawa K, Kitahara H, Okamune A, Sugiura S, Noguchi N, Yamamoto E
  • Journal Title: J Oral Med Pathol Volume: 40 Pages: 693-8
  • DOI: Doi:10.1111/j.1600-0714.2011.01032.x.
  • Peer Reviewed
• [Journal Article] Two elderly patients with advanced maxillary gingival carcinoma with complete response to concurrent radiotherapy and S-1 chemotherapy (2010)
  • Author(s): Yoshizawa K, Nozaki S, Yoshida K, Kawashiri S, Kato K, Nakagawa K, Yamamoto E
  • Journal Title: Oral and Maxillofacial Surgery Volume: 22 Pages: 94-98
  • DOI: Doi:10.1016/j.ajoms.2009.08.003.
  • Peer Reviewed
• [Journal Article] Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma (2009)
  • Author(s): Yoshizawa K, Nozaki S, Okamune A, Kitahara H, Ohara T, Kato K, Kawashiri S, Yamamoto E
  • Journal Title: J Oral Med Pathol Volume: 38 Pages: 535-9
  • DOI: Doi:10.1111/j.1600-0714.2009.00762.x.
  • Peer Reviewed
• [Journal Article] Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma (2009)
  • Author(s): Ohara T, Kawashiri S, Tanaka A, Noguchi N, Kitahara H, Okamune A, Kato K, Hase T, Nakaya H, Yoshizawa K
  • Journal Title: Pathol Oncol Res Volume: 15 Pages: 429-36
  • DOI: Doi:10.1007/s12253-008-9142-9.
  • Peer Reviewed
• [Presentation] uPA, uPAR and Maspin expression as a biomarker in invasive oral squamous cell carcinoma (2011)
  • Author(s): Yoshizawa K, Kawashiri S, 他4名
  • Organizer: 3rd International Conference on Innovative Approach in Head & Neck Oncology
  • Place of Presentation: Palau de Congressos de Catalunya(Barcelona, Spain)
  • Year and Date: 2011-02-26
• [Presentation] 口腔扁平上皮癌におけるMaspin発現およびuPA/uPAR発現-浸潤様式と予後との関連について- (2011)
  • Author(s): 吉澤邦夫、能崎晋一, 他10名
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 崇城大学市民ホール(熊本)
  • Year and Date: 2011-01-28
• [Presentation] 口腔扁平上皮癌におけるMaspin発現とuPA/uPAR発現について (2010)
  • Author(s): 吉澤邦夫、能崎晋一, 他7名
  • Organizer: 第28回日本口腔腫瘍学会総会
  • Place of Presentation: 学術総合センター(東京)
  • Year and Date: 2010-01-28
• [Presentation] 口腔扁平上皮癌細胞の正所性移植モデルにおける浸潤像の検討 (2009)
  • Author(s): 川尻秀一、吉澤邦夫、山本悦秀
  • Organizer: 第63回日本口腔科学会
  • Place of Presentation: アクトシティ浜松(静岡)
  • Year and Date: 2009-04-17