2010 Fiscal Year Final Research Report
The role of regulatory T cells induced by CCL22+ IDO+ dendritic cells in the oral cancer.
| Project/Area Number |
21791984
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
WATANABE Yoshiko Hamamatsu University School of Medicine, 医学部, 助教 (10444358)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔扁平上皮癌 / 免疫担当細胞 / ケモカイン |
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| Research Abstract |
We examined the infiltration of regulatory T cells in the oral squamous cell carcinoma. CD4+CD25+CD69+Foxp3+ regulatory T cells abundantly infiltrated to the cancer nest. We revealed that although total Tregs had no significant impact on survival, higher stromal CCR4+ (one of the Th2 chemokine receptors) Treg number was associated with a reduced survival time.
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