2010 Fiscal Year Final Research Report
Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family
| Project/Area Number |
21791985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
KATAGIRI Wataru Nagoya University, 医学系研究科, 助教 (10437030)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Wntシグナル / 骨再生医療 / 幹細胞 / MSC / sFRP-3 |
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| Research Abstract |
Recently it has been revealed that Wnt signaling pathway regulates the osteoblastic differentiation of human mesenchymal stem cells (hMSCs). We used sFRP-3, the antagonist of Wnt, to regulate this signaling and investigated the effect on osteoblastic differentiation of hMSCs in vitro and in vivo. It was revealed that the addition of sFRP-3 showed early differentiation and mineralization of hMSCs, and also showed early bone regeneration in animal model. These findings indicated the possibility of novel bone regenerative medicine using sFRP-3.
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