The participation of micro RNA acquiring the ability with high-invasiveness via Epithelial-mesenchymal Transition in squamous cell carcinoma

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791999
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: ONO Shigehiro Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (70379882)
• Project Period (FY): 2009 – 2010
• Keywords: 臨床腫瘍学

Research Abstract

The aim of this study was to find sigunificant microRNAs for acquiring high-invasiveness in SCC cell lines using microRNA microarrays. As a results of the investigation, I have identified 9 microRNAs related infiltration. These results suggest that identified microRNAs in this research will be candidates of a cancer therapy target.

Research Products

• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and-unstained areas. (2010)
  • Author(s): Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M, Shigeishi H, Takata T, Kamata N.
  • Journal Title: Oncol Rep. 24(1) Pages: 9-14
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (2009)
  • Author(s): Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N.
  • Journal Title: Int J Oncol. 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N.
  • Journal Title: Int J Cancer. 124(12) Pages: 2837-2844
  • Peer Reviewed
• [Presentation] EMT型口腔扁平上皮癌細胞におけるgamma-secretase inhibitor抵抗性の解析 (2009)
  • Author(s): 東川晃一郎, 田中扶美, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 口腔扁平上皮癌細胞における高度浸潤能獲得機構の解析 (2009)
  • Author(s): 田中扶美, 東川晃一郎, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] A Snail-induced secretory protein associated with the invasiveness of squamous cell carcinoma (2009)
  • Author(s): Tanaka F, Higashikawa K, Tobiume K, Ono S, Shigeishi H, Kamata N
  • Organizer: 第68回日本癌学会・学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03