2010 Fiscal Year Final Research Report

Development of combined therapy of oral cancer of which molecular target survivin and NF-・B

Research Project

Project/Area Number	21792006
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	The University of Tokushima
Principal Investigator	TAKAMARU Natsumi The University of Tokushima, 病院, 助教 (40513031)
Project Period (FY)	2009 – 2010
Keywords	survivin / NF-・B / 分子標的薬
Research Abstract	[Result] Rate of survivin expression in oral squamous cell carcinoma patients was 88%. localization of survivin is a positive-type nucleus and cytoplasm, cytoplasm negative nucleus-positive type and negative-type nucleus and the cytoplasm, was classified into three groups. Between the degree of differentiation and the expression of survivin in cancer was not associated, but showed a correlation between nuclear survivin expression in invasion style, Yamamoto-Kohama classification. [Conclusion] Expression of survivin in oral squamous cell carcinoma and enhance its level of expression was suggested to be related to invasion style.

(2 results)