2010 Fiscal Year Final Research Report
The mechanisms of resistance to apoptosis in oral cancer cells : New strategy to overcome cancer metastases
| Project/Area Number |
21792010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
HINO Satoshi Ehime University, 医学部附属病院, 講師 (90359927)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔癌 / 転移 / アポトーシス / アノイキス / TRAIL |
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| Research Abstract |
In this study I focused on the extrinsic apoptosis pathways, to determine which components influence metastasis. Poorly-metastatic human oral cancer cells were sensitive to TRAIL, whereas highly-metastatic cancer cells showed robust resistance. Further understanding of how sensitivity might be augmented comes from the observation that TRAIL receptor dose not localize on cell surface in highly-metastatic cancer cells.
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