Elucidation of mechanism underlying 5-FU resistance in oral cancer using genomic analysis and application to multimodal personalized medicine

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: NAKAYAMA Hideki Kumamoto University, 医学部附属病院, 助教 (70381001)
• Project Period (FY): 2009 – 2010
• Keywords: 臨床腫瘍学 / 抗癌剤耐性

Research Abstract

In the present study, to identify novel molecules associated with the 5-FU resistance of OSCC, we established a 5-FU-resistant OSCC cell line over a 2-year period, and found that an overexpression of cIAP2 confers 5-FU resistance in the cells. Furthermore, an immunohistochemical analysis using OSCC patient tissue samples demonstrated that increased expression of cIAP2 resulted in enhanced resistance to 5-FU-based chemoradiotherapy and a poor prognosis.

Research Products

• [Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Nomura T, Murakami R, Toya R, Teshima K, Nakahara A, Hirai T, Hiraki A, Nakayama H, Yoshitake Y, Ota K, Obayashi T, Yamashita Y, Oya N, Shinohara M.
  • Journal Title: Int J Radiat Oncol Biol Phys. 76(5) Pages: 1347-1352
  • Peer Reviewed
• [Journal Article] Radiation-induced parotid gland changes in oral cancer patients : correlation between parotid volume and saliva production. (2010)
  • Author(s): Teshima K, Murakami R, Tomitaka E, Nomura T, Toya R, Hiraki A, Nakayama H, Hirai T, Shinohara M, Oya N, Yamashita Y.
  • Journal Title: Jpn J Clin Oncol. 40(1) Pages: 42-46
  • Peer Reviewed
• [Journal Article] 歯性感染症が原因で生じたと考えられた敗血症性肺塞栓症の1例 (2010)
  • Author(s): 吉田遼司、中山秀樹、永田将士、吉武義泰、手島慶子、篠原正徳
  • Journal Title: 日本口腔外科学会雑誌 56 Pages: 49-53
  • Peer Reviewed
• [Journal Article] PTCH1遺伝子のミスセンス変異が認められた母斑基底細胞癌症候群の1例 (2010)
  • Author(s): 吉武義泰、中山秀樹、福間大喜、尾木秀直、平木昭光、篠原正徳
  • Journal Title: 日本口腔外科学会雑誌 56 Pages: 40-44
  • Peer Reviewed
• [Journal Article] 8歳女児の下顎骨骨折に対して観血的整復固定術と保存的治療を併用した1例 (2010)
  • Author(s): 高宗康隆、中山秀樹、難波亜弥、福間大喜、田中拓也、永田将士、吉武義泰、尾木秀直、篠原正徳
  • Journal Title: 日本口腔顎顔面外傷学会誌 9(2) Pages: 109-114
  • Peer Reviewed
• [Journal Article] Periodontal Status And Prevotella Intermedia Antibody In Acute Coronary Syndrome. (2009)
  • Author(s): Soejima H, Oe Y, Nakayama H, Matsuo K, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Shinohara M, Izumi Y, Ogawa H.
  • Journal Title: Int J Cardiol. 137(3) Pages: 304-306
  • Peer Reviewed
• [Journal Article] Significant Association Between Score of Periodontal Disease and Coronary Artery Disease Heart and Vessels (2009)
  • Author(s): Oe Y, Soejima H, Nakayama H, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Matsuo K, Shinohara M, Izumi Y, Ogawa H.
  • Journal Title: 24(2) Pages: 103-107
  • Peer Reviewed
• [Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. (2009)
  • Author(s): Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
  • Journal Title: Clin Cancer Res. 15(17) Pages: 5426-5434
  • Peer Reviewed
• [Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cell carcinoma cells (2010)
  • Author(s): Masashi Nagata, Hideki Nakayama, Yoshihiro Yoshitake, Daiki Fukuma, Takuya Tanaka, Ryoji Yoshida, Yasuo Takamune, Hidenao Ogi, Kenta Kawahara, Yoshihiro Nakagawa, Masanori Shinohara
  • Organizer: 第69回日本癌学会
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 20100922-20100924
• [Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cells carcinoma cells (2010)
  • Author(s): Hideki Nakayama, Masashi Nagata, Yoshihiro Yoshitake, Daiki Fukuma, Tak uya Tanaka, Ryoji Yoshida, Yasuo Takamu ne, Hidenao Ogi, Kenta Kawahara, Yoshih iro Nakagawa, Masanori Shinohara
  • Organizer: 第51回大韓口腔顎顔面外科学会
  • Place of Presentation: 韓国 清州 ラマダプラザ清州ホテル
  • Year and Date: 20100422-20100424
• [Presentation] 5-フルオロウラシル耐性口腔扁平上皮癌細胞の樹立とその細胞特性(Establishmentand characterization of 5-fluorouracil-resistant oral squamouscell carcinoma cell) (2009)
  • Author(s): 永田将士, 中山秀樹, 吉武義泰, 田中拓也, 吉田遼司, 福間大喜, 高宗康隆, 尾木秀直, 太田和俊, 平木昭光, 大林武久, 篠原正徳
  • Organizer: 第68回日本癌学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20091001-20091003
• [Presentation] ヒト口腔扁平上皮癌細胞株を用いた5-FU耐性株の樹立と機能解析 (2009)
  • Author(s): 中山秀樹, 田中拓也, 吉武義泰, 高宗康隆, 福間大喜, 吉田遼司, 尾木秀直, 篠原正徳, 永田将士
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 20090610-20090612
• [Remarks] ホームページ等
  • URL: http://www2.kuh.kumamoto-u.ac.jp/oralsurgery/