2010 Fiscal Year Final Research Report

Analysis of the mechanism of metastasis mediated ADAM-17 in adenoid cystic carcinoma.

Research Project

Project/Area Number	21792018
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Kumamoto University
Principal Investigator	TAKAMUNE Yasuo Kumamoto University, 医学部附属病院, 医員 (50467982)
Project Period (FY)	2009 – 2010
Keywords	腺様嚢胞癌 / 細胞接着 / プロテアーゼ / 癌の浸潤・転移
Research Abstract	We were cultured in Adenoid cystic carcinoma cells. In this study, After the effects of TNFα cytokines on CD44 cleavage were examined in several Adenoid cystic carcinoma cell lines using Western blotting . And we examined relationship between expression of ADAM17 and CD44 cleavage in mechanism for the tumor progression of ACC cell. The treatment of ACC cells with TNFα did not induce the generation of CD44 cleaved. We have to consider that cell lines after stimulation with TNFα, we are looking for localization of CD44 intracellular domain location details.