2010 Fiscal Year Final Research Report

Analysis of the role of transcription factor in the formation of tumor microvassel in oral cancer

Research Project

Project/Area Number	21792022
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Sapporo Medical University
Principal Investigator	OGI Kazuhiro Sapporo Medical University, 医学部, 助教 (40433114)
Project Period (FY)	2009 – 2010
Keywords	がん微小環境 / HIF1 / NF-kappaB / 転写因子
Research Abstract	Hypoxia in tumor occurs in the majority of tumors, promoting angiogenesis, metastasis and resistance to chemotherapy. Although hypoxia seems to activate several cellular molecules and pathways, the overall molecular mechanism remains unknown. We performed HIF1 and NF-kappaB regulated cDNA plate array with oral squamous cell carcinoma under hypoxia and normoxia. We obtained a plate based array data for profiling 23 HIF-regulated genes and 23 NF-kappaB-regulated genes. There are some difference among oral squamous cell carcinoma.