2010 Fiscal Year Final Research Report
Functional analysis of MIA, which is the novel lymphangiogenic marker of oral cancer
| Project/Area Number |
21792023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
SASAHIRA Tomonori Nara Medical University, 医学部, 助教 (90405374)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔癌 / MIA / 血管新生 / リンパ管新生 |
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| Research Abstract |
We examined the role of MIA in oral cancer. We clarified MIA involves tumor growth, invasion, and apoptosis-resistant in oral squamous cell carcinoma. We also found MIA accelerates angiogenesis and lymphangiogenesis by induction of VEGF-A, VEGF-C, and VEGF-D and MIA is poor prognostic factor in oral cancer. These results suggested that MIA is a useful diagnostic and therapeutic target of oral cancer.
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