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2010 Fiscal Year Final Research Report

Development of the oral cancer diagnosis system model by the tumor angiography using the nanobubble and ultrasound

Research Project

  • PDF
Project/Area Number 21792026
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

IWANAGA Kenjiro  Kyushu Dental College, 歯学部, 助教 (20448484)

Project Period (FY) 2009 – 2010
Keywords腫瘍 / 口腔癌診断 / ナノバブル / 超音波
Research Abstract

We develop the system which can diagnose a tumor depth using the new nanobubble which is applicable for a diagnosis, treatment of oral cancer. We made 4-Nitroquinoline 1-Oxide-induced tongue cancer rat model. Under ultrasonographic monitoring, elastic needles with a metal core were introduced to mark a deep surgical margin of 5 mm from the deepest tumor invasion front. Surgical resection was carried out using elastic needle as the deepest surgical clearance mark. The resected specimen was immediately immersed in gelatin solution maintaining its original shape and orientation, and refrigerated to solidify. Ultrasonographic observations of the gelatin embedded specimens were performed to confirm the surgical clearance. Immediate surgical clearance of the resected specimens could be easily verified intraoperatively. Further, sonographic marking showed a good correlation with the histological margins.

  • Research Products

    (10 results)

All 2010 2009

All Journal Article (2 results) Presentation (8 results)

  • [Journal Article] Ultrasonography for Intraoperative Determination of Tumor Thickness and Resection Margin in Tongue Carcinomas.2010

    • Author(s)
      M.Kodama., A.Khanal, M.Habu, K.Iwanaga, I.Yoshioka, T, Tanaka., Y, Morimoto., K.Tominaga.
    • Journal Title

      J Oral Maxillo fac Surg. 68(8)

      Pages: 1746-1752

  • [Journal Article] Targeted drug delivery system for oral cancer therapy using sonoporation. Journal of Oral Pathology and Medicine.2009

    • Author(s)
      Hironobu Maeda, Kazuhiro Tominaga, Kenjiro Iwanaga, Fuminori Nagao, Manabu Habu, Toshiyuki Tsujisawa, Yuji Seta, Kuniaki Toyoshima, Jin-ichi Fukuda, Tatsuji Nishihara.
    • Journal Title

      J Oral Pathol Med. 38(7)

      Pages: 572-579

  • [Presentation] Effects of ultrasound and EDBL on cytotoxity in Ca9-2.2010

    • Author(s)
      Kenjiro Iwanaga, Osamu Takahashi, Toshinori Okinaga, Michinao Kawano, Wataru Ariyoshi, Tatsuji Nishihara, Kazuhiro Tominaga.
    • Organizer
      第58回JADR
    • Place of Presentation
      北九州
    • Year and Date
      20101100
  • [Presentation] 口腔扁平上皮癌細胞株におけるドキソルビシン含有バブルリポソームと超音波との併用による致死活性効果について2010

    • Author(s)
      岩永賢二郎,_高橋理,_西原達次,_冨永和宏
    • Organizer
      22年度 第1回日本超音波分子診断治療研究会
    • Place of Presentation
      札幌
    • Year and Date
      20100800
  • [Presentation] 超音波を用いた遺伝子・薬剤導入法とその医療応用について.ニューセラミックス懇話会2010

    • Author(s)
      岩永賢二郎
    • Organizer
      バイオ関連セラミック分科会第29回研究会
    • Place of Presentation
      大阪 島津製作所関西支社
    • Year and Date
      2010-05-28
  • [Presentation] ナノ・マイクロバブルと超音波を用いた遺伝子・薬剤導入法と顎顔面口腔領域への応用2009

    • Author(s)
      岩永賢二郎
    • Organizer
      第8回日本超音波治療研究会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-28
  • [Presentation] Development of gene and drug delivery system using nano-microbubbles and ultrasound and its application in oral and maxillofacial field.2009

    • Author(s)
      K.Iwanaga, K.Tominaga, O.Takahashi, M.Kawano, T.Nishihara.
    • Organizer
      The Second Japan-Korea Joint Symposium on Bio-microsensing Technolog.
    • Year and Date
      2009-11-13
  • [Presentation] A new treatment strategy for oral cancer using sonoporation.2009

    • Author(s)
      O. Takahashi, K.Iwanaga, M.Habu, I.Yoshioka, T.Nishihara, K.Tominaga.
    • Organizer
      The 48th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
    • Place of Presentation
      Seoul
    • Year and Date
      2009-10-30
  • [Presentation] ソノポレーション法を応用した骨芽細胞の分化誘導2009

    • Author(s)
      河野通直、岩永賢二郎、辻澤利行、西原達次
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
  • [Presentation] ナノバブルと超音波を用いた遺伝子導入による顎関節炎の次世代治療法の開発2009

    • Author(s)
      岩永賢二郎,_土生学,_吉岡泉,_冨永和宏
    • Organizer
      第22回日本顎関節症学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25

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Published: 2012-02-13   Modified: 2016-04-21  

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