Clarification of Novel Metastatic mechanism in Oral Squamous Cell Carcinoma

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: ONDA Takeshi Tokyo Dental College, 歯学部, 助教 (30433949)
• Project Period (FY): 2009 – 2010
• Keywords: 扁平上皮癌 / プロテオミクス / 癌遺伝子 / 癌抑制遺伝子

Research Abstract

The aim of this study was to identify novel metastasis-associated gene of oral squamous cell carcinoma by using DNA microarray on which all human genes are carried in order to make it possible to diagnose metastasis as well as to evaluate grade of tumor. Based on a global gene expression analysis on oral tissue, oral squamous cell carcinoma tissue and lymph node metastasis tissue, 75 of candidate genes including zinc finger DHHC-type containing 14(ZDHHC14) and Spleen tyrosine kinase(SYK) have been listed up. It has suggested a possible existence of more than 50 of genes with impaired expression, which are commonly recognized in each case, at least in oral squamous cell carcinoma, if not in all cases.

Research Products

• [Journal Article] Aberrant expression of the ZDHHC14 gene in squamous cell carcinoma of the human tongue. (2010)
  • Author(s): Onda T, Yamamoto N, Kuroiwa T, Katakura A, Takano N, Shibahara T.
  • Journal Title: Asian Journal of Oral and Maxillofacial Surgery. 22(4) Pages: 187-192
• [Journal Article] Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human Oral squamous cell carcinoma. (2009)
  • Author(s): Ogane S, Onda T, Takano N, Yajima T, Uchiyama T, Shibahara T.
  • Journal Title: Int J Cancer. 124(11) Pages: 2651-2657
• [Presentation] 口腔扁平上皮癌由来細胞株の2D-DIGE解析 (2011)
  • Author(s): 恩田健志
  • Organizer: 第29回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 崇城大学市民ホール(熊本市)
  • Year and Date: 2011-01-27
• [Presentation] Over expression of zinc finger, DHHC-type containing 14 gene located on chromosome 6q25.3 in human tongue squamous cell carcinoma. (2010)
  • Author(s): Onda T
  • Organizer: 第9回Asian Congress on Oral and Maxillofacial Surgery.
  • Place of Presentation: Kuala Lumpur Convention Centreマレーシア(クアラルンプール)
  • Year and Date: 2010-11-26
• [Presentation] Aberrant expression of ZDHHC14 gene in human tongue squamous cell Carcinoma. (2009)
  • Author(s): Onda T
  • Organizer: 第15回European Society for Medical Oncology, 第34回European Cancer Organisation.
  • Place of Presentation: International Congress Centrum,ドイツ(ベルリン)
  • Year and Date: 2009-09-22