2010 Fiscal Year Final Research Report
Effects of GABAergic compounds on the accumbal catecholaminergic activity
| Project/Area Number |
21792034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
UCHIDA Takuya Nihon University, 歯学部, 助教 (10409104)
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| Project Period (FY) |
2009 – 2010
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| Keywords | GABA / カテコラミン / 大脳基底核 / 抗不安薬 / 口腔ジスキネジア |
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| Research Abstract |
The ventral part of striatum called nucleus accumbens is one of the terminal areas of the mesolimbic dopaminergic neurons. It has been shown that the GABA receptor subtype agonists failed to decrease, but its antagonists increased the accumbal dopamine (DA) efflux. Since the GABA synthesis inhibitor enhanced the accumbal DA efflux, but the involvement of accumbal GABA receptor subtypes are unknown. Therefore, we investigated the roles of GABA receptor subtypes in the increase of accumbal DA efflux in freely moving rats by using the in vivo brain microdialysis technique. SKF38393, a benzazepine derivative D_1 receptor agonist is widely used in order to examine the GABA-DA interaction in the striatal structures. SKF38393 is known to increase the striatal DA efflux when applied locally into the dorsal striatum. We analysed the roles of the Ca^<2+> and the intracellular DA pools in the SKF38393-induced striatal DAefflux.
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