2010 Fiscal Year Final Research Report
The study of the BNCT effect using the transferrin conjugate boron carriers on head and neck cancer
| Project/Area Number |
21792042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
ITO Yuichi Osaka Medical College, 医学部, 助教 (10530701)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ホウ素中性子補足療法 / BSH / BNCT / 口腔悪性腫瘍 |
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| Research Abstract |
We conducted a study using Liposome to examine the augmentation of the BNCT effect on oral squamous cell carcinoma. When it modified BSH in TF-PEG-liposome, it was confirmed immunohistochemically that the BSH transportation in cells was accomplished surely. It was actually confirmed that TF-PEG-liposome significantly showed a tumor killing effect as compared with BSH when we conducted neutron to cells. The results suggested that TF-PEG-liposome was useful for making BNCT effect increase.
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