2010 Fiscal Year Final Research Report
The clinical study of the boron neutron capture therapy (BNCT) in patients with oral cancer
| Project/Area Number |
21792043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KIMURA Yoshihiro Osaka Medical College, 医学部, 助教 (00351388)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 硼素中性子捕捉療法 / BNCT / 口腔癌 |
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| Research Abstract |
The T/N ratio by BPA-PET in front of BNCT is 1.9-4.0.
The neutron exposure is up to 20.1-39.1Gy-Eq, and the minimum is 9.12 - 31.9Gy-Eq.
The neutron exposure in the oral mucosa is 9.03-15.7Gy-Eq.
The normal skin surface is 2.81-7.64Gy-Eq.
A reduction effect of tumor is CR two cases, PR five cases, PD one case A survival period after BNCT is 4-44 months.
For adverse side effects, mucositis, fatigue, alopecia, impaired taste, and pharyngeal edema were observed.
Neither myelosuppression nor osteomyelitis of the jaw bone was observed.
Side effect
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