2010 Fiscal Year Final Research Report
Elucidation of the Mechanism of Odontblast Differentiation by Bone Morphogenetic Factor and Application to Regeneration
| Project/Area Number |
21792053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MARUYA Yuriko Tohoku University, 大学院・歯学研究科, 助教 (60400389)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小児歯科学 / 歯髄幹細胞 / GDF-5 |
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| Research Abstract |
Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell.
GDF-5 promoted production of molecules characteristic for odontoblastic phenotype. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.
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