2010 Fiscal Year Final Research Report
Development of bone regeneration system with siRNA-mediated gene knock-down
| Project/Area Number |
21792059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGAHAMA Kouhei The University of Tokyo, 医学部附属病院, 助教 (60401361)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯科矯正 / siRNA |
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| Research Abstract |
This study aimed to induce bone regeneration by inhibiting signaling factors that worked as inhibitors in osteogenic signaling pathway, focusing on BMP, hedgehog, Wnt, and Runx2 signaling pathways. We generated 11 siRNAs for those factors and confirmed that each siRNA knocked down target genes. Among them, the combination of siRNAs that shows promising effects on osteogenic differentiation is being examined in animal bone defect model.
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[Journal Article] The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis.2010
Author(s)
Inokuchi T, Kawamoto T, Aoki K, Aoki A, Nagahama K, Baba Y, Suzuki S, Shibayama M, Mano Y, Ohya K, Moriyama K.
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Journal Title
Cleft Palate Craniofac J. 47(4)
Pages: 382-392
Peer Reviewed
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