2010 Fiscal Year Final Research Report
Investigation of identification and purification of human deciduous tooth-derived stem cells
| Project/Area Number |
21792071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KAWANABE Noriaki Okayama University, 岡山大学病院, 講師 (00397879)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯科矯正学 |
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| Research Abstract |
In the present study, we investigated if SSEA-4 could serve as a marker to distinguish human deciduous tooth-derived stem cells. Clonal assay demonstrated that 68.4% of SSEA-4-positive periodontal ligament (PDL) cells and 85.7% of SSEA-4-positive dental pulp (DP) cells exhibit either adipogenic or osteogenic potential. In addition, these cells showed adipogenic, osteogenic, and chondrogenic differentiation. These results showed that SSEA-4 can be used to promote the enrichment of stem cells from the PDL and DP of human deciduous teeth.
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[Journal Article] Sox9 Expression during Fracture Repair.
Author(s)
Yuko Shintaku, Takashi Murakami, Takeshi Yanagita, Noriaki Kawanabe, Tomohiro Fukunaga, Kiyomi Matsuzaki, Setsuko Uematsu, Yasuhiro Yoshida, Hiroshi Kamioka, Teruko Takano-Yamamoto, Kenji Takada, Takashi Yamashiro.
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Journal Title
Cells Tissues Organs in press
Peer Reviewed
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