2011 Fiscal Year Final Research Report
Elucidation of the mechanism of osteoblast differentiation inhibition by LPS derived from A. a.
| Project/Area Number |
21792074
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 歯周病原性菌 / 小児 / 細胞間ネットワーク |
|---|
| Research Abstract |
Lipopolysaccharide(LPS) derived from A. ggregatibacter actinomycetemcomitans(A. a) suppressed osteoblast differentiation and LPS derived from A. a inhibits osteoblast differentiation through an intercellular network. LPS was a potential inhibitor. Alterations in intracellular Cx43 localization may be involved in intercellular network inhibition.
|
