Central mechanisms of circadian entrainment via oral functions

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792075
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: NAKAMURA Wataru Osaka University, 大学院・歯学研究科, 特任准教授 (60372257)
• Project Period (FY): 2009 – 2010
• Keywords: 体内時計 / 概日リズム / 環境同調 / 時計遺伝子 / 予知行動 / 制限給餌

Research Abstract

Many animals have an ability to anticipate periodic food availability. In this study, we have examined the food anticipatory activity in circadian clock deficient mice. Some KO mice which have slightly differences in intrinsic circadian period show limited entrainment to various period of feeding ; the other molecular clock deficient mice do not. These results suggest that the canonical molecular clock may not drive food anticipatory behavioral activity, but may control it as a circadian manner.

Research Products

• [Journal Article] Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes. (2010)
  • Author(s): Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y.
  • Journal Title: Biochemistry. 49(37) Pages: 8053-61
• [Journal Article] 概日行動リズムを制御する視交叉上核 (2010)
  • Author(s): 中村渉
  • Journal Title: 時間生物学 16巻 Pages: 3-9
• [Journal Article] Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. (2010)
  • Author(s): Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 107(8) Pages: 3846-3851
• [Journal Article] Behavioral analysis of circadian rhythms: Entraining the circadian clock and determining the food-entrainable oscillator mechanism. (2010)
  • Author(s): Nakamura W.
  • Journal Title: Sleep Biol Rhythms. 8(1) Pages: 28-33
• [Presentation] マウス行動概日リズムの光同調と非光同調 (2010)
  • Author(s): 中村渉
  • Organizer: 第16回日本光生物学協会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-08-10
• [Presentation] The food-entrainable oscillator does not drive anticipatory activity, but controls it as circadian manner. (2010)
  • Author(s): Nakamura W.
  • Organizer: 12th Biennial Meeting of Society for Research on Biological Rhythms.
  • Place of Presentation: FL (USA)
  • Year and Date: 2010-05-23
• [Presentation] 概日リズムを制御する階層的神経回路構造の解明 (2010)
  • Author(s): 中村渉
  • Organizer: 第8回口腔医科学フロンティア
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-06
• [Presentation] 概日行動リズムを制御する視交叉上核 (2009)
  • Author(s): 中村渉
  • Organizer: 日本時間生物学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-27
• [Presentation] Food-entrainment: current controversies and recent progress. (2009)
  • Author(s): Nakamura W.
  • Organizer: XI. Congress of the European Biological Rhythms Society.
  • Place of Presentation: フランス・ストラスブール
  • Year and Date: 2009-08-27
• [Presentation] Circadian output in the suprachiasmatic nucleus. (2009)
  • Author(s): Nakamura W.
  • Organizer: XI. Congress of the European Biological Rhythms Society.
  • Place of Presentation: フランス・ストラスブール
  • Year and Date: 2009-08-26
• [Presentation] Different property of food anticipatory activity in BMAL1-deficient mice. (2009)
  • Author(s): Nakamura W.
  • Organizer: International Symposium on Biological Rhythm.
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-04