Abnormality of receptor mechanism and cartilage in transgenic mice with mutant PTH/PTHrP receptor

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792098
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: SHIMOMURA Junko The Nippon Dental University, 新潟生命歯学部, 准教授 (00386286)
• Project Period (FY): 2009 – 2010
• Keywords: 骨 / 軟骨

Research Abstract

The aim of this study was to elucidate the altered signaling pathway and abnormal cell differentiation caused by the PTH/PTHR receptor with P132L mutation (PTH-R^<P132L>), which is overexpressed in murine cartilage. Transgenic mice carrying PTH-R^<P132L> were generated and histologically analyzed. As a consequence, the histological phenotype of cartilage of PTH-R^<P132L> transgenic mice was similar to the knockout mice of PTHrP or PTH-R.

Research Products

• [Journal Article] FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line (2010)
  • Author(s): Li M, Seki Y, Freitas PH, Nagata M, Kojima T, Sultana S, Ubaidus S, Maeda T, Shimomura J, Henderson JE, Tamura M, Oda K, Liu Z, Guo Y, Suzuki R, Yamamoto T, Takagi R, Amizuka N
  • Journal Title: J Electron Microscopy 59 Pages: 227-236
  • Peer Reviewed
• [Journal Article] 上下顎歯列弓の不調和を伴う骨格性下顎前突の1例-上顎2分割Le FortI型骨切り術と下顎枝垂直骨切り術の併用による咬合改善- (2010)
  • Author(s): 黒木大雄, 下村-黒木淳子, 遠藤敏哉, 伊藤秀俊, 水谷太尊, 山口晃
  • Journal Title: 日本顎変形症学会雑誌 20巻33号 Pages: 234-244
  • Peer Reviewed
• [Journal Article] Tannerella forsythia and the HLA-DQB1 allele are associated with susceptibility to periodontal disease in Japanese adolescents (2009)
  • Author(s): Shimomura-Kuroki J, Yamashita K, Shimooka S
  • Journal Title: Odontology 97 Pages: 32-37
  • Peer Reviewed
• [Journal Article] 副甲状腺ホルモン受容体点突然変異と細胞内局在異常 (2009)
  • Author(s): 下村-黒木淳子
  • Journal Title: 小児歯科学雑誌 47(4) Pages: 550-554
  • Peer Reviewed
• [Journal Article] 骨細胞・骨細管系におけるFGF23とDMP-1の免疫局在 (2009)
  • Author(s): Sobhan Ubaidus, Sara Sultana, 織田公光, 小島拓, 李敏啓, 鈴木礼子, 柳鋳晟, 網塚憲生, 小沢英浩, 下村-黒木淳子
  • Journal Title: The BONE 23(4) Pages: 3-8
• [Presentation] PTH/PTHrP受容体トランスジェニックマウスにおける骨・軟骨異常 (2010)
  • Author(s): 下村-黒木淳子, 松田貴絵, 網塚憲生, 下岡正八
  • Organizer: 平成22年度日本小児歯科学会秋期大会(小児歯科学雑誌,48(5); 569, 2010.)
  • Place of Presentation: 郡山
  • Year and Date: 20101202-20101203
• [Presentation] Expression of DMP-1 in alveolar bone during physiological tooth movement. (2010)
  • Author(s): Matsuda K, Shimomura-Kuroki J, Haga M, Yoshie S, Shimooka S.
  • Organizer: The 88^<th> General Session & Exhibition of the IADR(J of Dent.Res., 4255, 2010.)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100714-20100717
• [Presentation] マウス臼歯の生理的遠心移動による歯槽骨でのDMP-1の発現様式 (2010)
  • Author(s): 松田貴絵, 下村-黒木淳子, 羽下麻衣子, 吉江紀夫, 下岡正八
  • Organizer: 第48回日本小児歯科学会(小児歯科学雑誌,48(2);212,2010.)
  • Place of Presentation: 名古屋
  • Year and Date: 20100519-20100520
• [Presentation] 小児における口腔疾患発症リスクの評価 (2009)
  • Author(s): 下村-黒木淳子, 山下-松田貴絵, 本間裕章, 田中聖至, 下岡正八
  • Organizer: 第46回日本小児歯科学会大会(小児歯科学雑誌,47(2): 379, 2009.)
  • Place of Presentation: 大阪
  • Year and Date: 20090514-20090515
• [Presentation] 骨改造現象に関わる骨代謝調節因子に関する研究 (2009)
  • Author(s): 下村-黒木淳子
  • Organizer: 第47回日本小児歯科学会大会奨励賞受賞講演,第47回日本小児歯科学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-15
• [Book] クインテッセンス出版株式会社,東京 (2009)
  • Author(s): 下村淳子, 下岡正八
  • Total Pages: 14-49
  • Publisher: 第2章,小児歯科に必要な心身の発育,新小児歯科学第3版(下岡正八他編)
• [Remarks] ホームページ等
  • URL: http://www.ngt.ndu.ac.jp/guide/kouza/dental11.html