2010 Fiscal Year Final Research Report
Identification of am3 gene and an underlying study for establishment of risk diagnostic procedure using SNPs
| Project/Area Number |
21792102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
NARIYAMA Megumi Tsurumi University, 歯学部, 助教 (90440304)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子遺伝学 / 歯の発育異常 / am3遺伝子 / リスク診断 / ELマウス |
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| Research Abstract |
The present study attempted to define genes causing an absence of the third molars in EL mice with the majority exhibiting the absence of all third molars. I analyzed the mRNA expressions of candidate genes (Lef1, Egf) in the am3 locus indicated with linkage analysis and other candidate genes (Shh, Pitx2, Bmp2, Bmp4) in the EL and control mice using Real-time PCR. The results of PCR suggest that Lef1, Egf, Bmp2, and Bmp4 are involved in the absence of the third molars in EL mice.
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