Elucidation of immune escape mechanisms by periodontopathic bacteria

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792112
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: HONDA Tomoyuki Niigata University, 医歯学系, 特任助教 (30447635)
• Research Collaborator: TAKAHASHI Naoki 新潟大学, 大学院・医歯学総合研究科 ; KAJITA Keiko 新潟大学, 医歯学総合病院, 医員 ; OKUI Takafumi 新潟大学, 医歯学系, 特任助教
• Project Period (FY): 2009 – 2010
• Keywords: Porphyromonas gingivalis / LPS / microRNA / miR-146a

Research Abstract

P.gingivalis stimulation up-regulated the expression of miR-146a in macrophages. Over expression of miR-146a in macrophages attenuated the release of P.gingivalis-induced inflammatory cytokines. Further studies are required to elucidate the exact role of microRNA in periodontal pathogenesis.

Research Products

• [Journal Article] IL-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. (2010)
  • Author(s): Takahashi N, Honda T, Domon H, Nakajima T, Tabeta K, Yamazaki K.
  • Journal Title: J Periodont Res. 45(4) Pages: 512-519
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells. (2010)
  • Author(s): Maekawa T, Takahashi N, Honda T, Yonezawa D, Miyashita H, Okui T, Tabeta K, Yamazaki K.
  • Journal Title: J Vasc Res. 47(4) Pages: 346-354
  • Peer Reviewed
• [Journal Article] Periodontitis associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. (2010)
  • Author(s): Nakajima T, Honda T, Domon H, Okui T, Kajita K, Ito H, Takahashi N, Maekawa T, Tabeta K, Yamazaki K.
  • Journal Title: J Periodont Res. 45(1) Pages: 116-122
  • Peer Reviewed
• [Presentation] Periodontal treatment improves arterial stiffness. (2010)
  • Author(s): Nakajima T, Honda T, Okui T, Kajita K,Domon H, Takahashi N, Maekawa T, TabetaK, Yamazaki K.
  • Organizer: AAP 2010 Annual Meeting in Honolulu
  • Year and Date: 2010-11-01
• [Presentation] bFGFがヒト歯根膜細胞のmicroRNA 発現に及ぼす影響 (2010)
  • Author(s): 奥井桂子, 本田朋之, 奥井隆文, 高橋直紀, 土門久哲, 宮内小百合, 山崎和久
  • Organizer: 第133回日本歯科保存学会2010年度秋季学術大会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-10-29
• [Presentation] Porphyromonas gingivalis LPS がmicroRNA発現に及ぼす影響 (2010)
  • Author(s): 本田朋之, 高橋直樹, 奥井桂子, 奥井隆文, 中島貴子, 多部田康一, 山崎和久
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松市
  • Year and Date: 2010-09-19
• [Presentation] ヒト歯肉上皮細胞のケモカイン産生におけるinterleukin (IL)-17の関与-IL-17受容体の発現とその機能解析- (2010)
  • Author(s): 高橋直紀, 前川知樹, 奥井隆文, 本田朋之, 多部田康一, 中島貴子, 山崎和久
  • Organizer: 第53回春季日本歯周病学会学術大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-14
• [Presentation] Porphyromonas gingivalis 抗原およびIL-6刺激は血管内皮細胞において転写因子Egr-1を介してMCP-1の産生を増強する (2009)
  • Author(s): 前川知樹, 高橋直紀, 本田朋之, 宮下博孝, 米澤大輔, 奥井隆文, 多部田康一, 山崎和久
  • Organizer: 第131回日本歯科保存学会2009年度秋季学術大会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-29
• [Presentation] 歯周炎患者におけるPorphyromonas gingivalisに対する抗体価と高感度CRPの関連性 (2009)
  • Author(s): 宮下博孝, 米澤大輔, 本田朋之, 奥井隆文, 梶田桂子, 前川知樹, 高橋直紀, 伊藤晴江, 中島貴子, 多部田康一, 山崎和久
  • Organizer: 第52回秋季日本歯周病学会学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2009-10-11
• [Presentation] Antibody levels to Porphyromonas gingivalis and CRP in periodontitis patients. (2009)
  • Author(s): Miyashita H, Honda T, Okui T,Kajita-Okui K, Maekawa T, TakahashiN,Ito H, Nakajima T, Tabeta K, Yamazaki K.
  • Organizer: 2nd Meeting of the IADR Pan Asian Pacific Federation.
  • Place of Presentation: Wuhan
  • Year and Date: 2009-09-23
• [Presentation] Porphyromonas gingivalis modulates chemokine expression in gingival epithelial cells. (2009)
  • Author(s): Takahashi N, Honda T, Tabeta K, YamazakiK.
  • Organizer: 87th General session of the IADR
  • Place of Presentation: Miami
  • Year and Date: 2009-04-02