2010 Fiscal Year Final Research Report
The role of regulatory T cell in Periodontitis regions
| Project/Area Number |
21792113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
ITO Harue Niigata University, 医歯学系, 助教 (30397145)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 制御性T細胞 / T細胞クローン / 歯周炎 |
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| Research Abstract |
Periodontal bacteria are the causative agents in periodontitis, but subsequent progression and disease severity are thought to be determined by the host immune responses. It was reported that CD4^+CD25^+ regulate T cell existed and might have roles in progress of periodontitis. The aim of this study was to make CD4+CD25+ Tr cell's roles in periodontitis. CD4^+CD25^+ Tr suppressed proliferation of CD4^+CD25- T cells. After CD4^+CD25^+ Tr was stimulate by Dynabeads HumanT-Activator CD3/CD28, The ability of suppression was reduced. This was suggested that the ability of suppression in CD4^+CD25^+ Tr might be reduced by the stimulation.
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