2010 Fiscal Year Final Research Report
Correlation between fibrinogen and IL-6 in progression of periodontitis-in vivo analyses-
| Project/Area Number |
21792118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
MOROZUMI Toshiya Niigata University, 医歯学総合病院, 助教 (20444151)
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| Project Period (FY) |
2009 – 2010
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| Keywords | フィブリノゲン / IL-6 / 歯周炎 |
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| Research Abstract |
Fibrinogen is an acute-phase protein synthesized both by hepatic and nonhepatic cells in response to proinflammatory cytokines such as IL-6. We have demonstrated that the -1420G/A, -854G/A and -148C/T polymorphisms in the β-fibrinogen promoter region are determinants of IL6-induced activity, and could be functional polymorphisms. While, it is reported that there is a strong linkage disequilibrium in some races among the 4 common polymorphisms (-1420G/A, -993C/T, -455G/A and -148C/T).
In the study, we performed the gene polymorphism analysis in the β-fibrinogen promoter region. The results indicated that the presence of the linkage disequilibrium among the 4 common polymorphisms in Japanese population.
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