2010 Fiscal Year Final Research Report
Analysis of novel periodontal ligament-specific molecules identified in human periodontal ligament full-length cDNA database.
| Project/Area Number |
21792119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
OZAWA Yasuhiro Osaka University, 歯学部附属病院, 医員 (30448146)
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| Research Collaborator |
FUJIHARA Chiharu 大阪大学, 歯学部附属病院, 専修歯科医
KAJIKAWA Tetuhiro 大阪大学, 大学院・歯学研究科, 大学院生
OZAKI Nobuhiro 大阪大学, 大学院・歯学研究科, 大学院生
AWATA Toshihito 大阪大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯根膜組織完全長cDNAライブラリ |
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| Research Abstract |
In this study, I analyzed human periodontal ligament full-length cDNA library ( Full-PerioGen database ) and found several genes which were highly expressed in human periodontal ligament tissues. Among of these genes, I focused on FLJ25143 and Cathepsin K of which functions in periodontal ligament were not known. I found that FLJ25143 and Cathepsin K regulated periodontal ligament cell functions, suggesting involvement of these molecules in homeostasis, repair and regeneration of periodontium.
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