Clarification of the function of extracellular matrix protein POEM in the osteogenesis

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Showa University
• Principal Investigator: MIYAZONO Agasa Showa University, 歯学部, 助教 (00514936)
• Co-Investigator(Renkei-kenkyūsha): KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939) ; YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
• Project Period (FY): 2009 – 2010
• Keywords: 歯周免疫機能学

Research Abstract

POEM(pre-osteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine phosphatase μ domain) gene expression was suppressed by TGF-β via ERK1/2 and JNK. To investigate function of POEM in osteoblasts and bone formation, we determined start point transcription.

Research Products

• [Presentation] エナメル芽細胞の分化に伴うCaspase-14の発現をTGF-βが促進する (2010)
  • Author(s): 宮園あがさ, 須澤徹夫, 山本剛, 小野美樹, 相澤怜, 臼井通彦, 立川哲彦, 槇宏太郎, 山本松男, 上條竜太郎
  • Organizer: Journal of Oral Scienses,p121, 2009(第52回歯科基礎医学会)
  • Place of Presentation: 船堀
  • Year and Date: 20100900
• [Presentation] エナメル芽細胞におけるCaspase-14の役割 (2009)
  • Author(s): 宮園あがさ, 須澤徹夫, 山本松男, 上條竜太郎
  • Organizer: Journal of Oral Scienses,p139, 2009(第51回歯科基礎医学会)
  • Place of Presentation: 新潟
  • Year and Date: 20090800
• [Presentation] LPA(lysophosphatidic acid)の歯肉扁平上皮癌細胞株Ca9-22に対する影響 (2009)
  • Author(s): 臼井通彦, 宮園あがさ, 府川有紀子, 林幸恵, 山本松男
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 20090700
• [Presentation] リゾリン脂質・Lysophosphatidic acid (LPA)の歯肉上皮細胞株Ca9-22への影響 (2009)
  • Author(s): 臼井通彦, 宮園あがさ, 山本松男
  • Organizer: 第130回日本歯科保存学会春季学術大会
  • Place of Presentation: 札幌
  • Year and Date: 20090600
• [Presentation] リゾリン脂質・LPA(lysophosphatidic acid)の破骨細胞前駆細胞株Raw264.7に対する影響 (2009)
  • Author(s): 臼井通彦, 宮園あがさ, 山本松男
  • Organizer: 口腔組織培養学会誌,19:49-50
  • Year and Date: 20090000