Effects of nicotine on the signal transduction in osteoclast precursors

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792132
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Nihon University
• Principal Investigator: TANAKA Hideki Nihon University, 歯学部, 専修研究員 (90434076)
• Project Period (FY): 2009 – 2010
• Keywords: 歯周病 / ニコチン / 破骨細胞

Research Abstract

Nicotine induces the expression of CA II, inflammatory cytokines and PGE2 in osteoclast precursors. In the presence of COX-2 inhibitor , nicotine did not induce CA II expression. These results suggest that PGE2 play a role in the induction of CA II expression by autocrine manner.

Research Products

• [Journal Article] IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells. (2010)
  • Author(s): Kitami S, Tanaka H, Kawato T, Tanabe N, Katono-Tani T, Zhang F, Suzuki N, Yonehara Y, Maeno M
  • Journal Title: Biochimie 92 Pages: 398-404
  • Peer Reviewed
• [Journal Article] Interleukin-17A induces cathepsin K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin E2 in osteoblasts. (2010)
  • Author(s): Zhang F, Tanaka H, Kawato T, Kitami S, Nakai K, Motohashi M, Suzuki N, Wang C, Ochiai K, Isokawa K, Maeno M
  • Journal Title: Biochimie 93 Pages: 296-305
  • Peer Reviewed
• [Presentation] 酪酸は骨芽細胞のCOX-1およびCOX-2発現増加を介してPGE2産生を促進する. (2010)
  • Author(s): 飯田隆文, 田中秀樹, 上遠野(谷)朋子, 桑原亜貴子, 川戸貴行, 田邊奈津子, 前野正夫, 川口隆彦
  • Organizer: プログラム:30,日本歯科保存学会2010年度春季学術大会(第132回)
  • Place of Presentation: 崇城大学市民ホール,熊本県
  • Year and Date: 20100000
• [Presentation] Butyric acid induces Coxs and PGE2 production in ROS17/2.8 cells. 1725 (2010)
  • Author(s): Iida T, Kawato T, Tanaka H, Katono-Tani T, Kuwabara A, Tanabe N, Kawaguchi T, Maeno M
  • Organizer: 88^<th> General Session & Exhibition of IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100000
• [Presentation] IL-17A suppresses proteinase expression and osteoclast differentiation in RAW264.7 cells. 4754 (2010)
  • Author(s): Kitami S, Tanaka H, Kawato T, Tanabe N, Motohashi M, Maeno M
  • Organizer: 88^<th> General Session & Exhibition of IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100000
• [Presentation] 酪酸は骨芽細胞の分化を抑制しPGE2産生を促進する.口腔衛生会誌60(4):417 (2010)
  • Author(s): 飯田隆文, 田中秀樹, 川戸貴行, 田邉奈津子, 神尾宣昌, 北見聡, 桑原亜貴子, 中井久美子, 前野正夫
  • Organizer: 第59回日本口腔衛生学会・総会
  • Place of Presentation: 朱鷺メッセ,新潟県
  • Year and Date: 20100000
• [Remarks] ホームページ等