2011 Fiscal Year Final Research Report

Study of IGF-I effect on anti-aging for the jawbone

Research Project

Project/Area Number	21792140
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Social dentistry
Research Institution	Tohoku University
Principal Investigator	KOJIMA Ikuho 東北大学, 大学院・歯学研究科, 助教 (80447169)
Project Period (FY)	2009 – 2011
Keywords	IGF-I / 骨 / アンチエイジング
Research Abstract	The results of IGF-I administration for normal rat were as follows. 1)Bone mineral density (BMD)analyzed by X-ray photograph increased in lower area of mandibular condyle. 2)On measurement about bone matrix ratio (BMR), BMR was greater in lower part of mandibular condyle (Cd)vertically divided into three parts, and was greater in central part of laterally divided Cd. 3)On measurement about osteoblast, the number of osteoblasts was greater in central and lower parts of vertically divided Cd, and in inside and outside parts of laterally divided Cd. 4)On measurement about osteoclast, the number of osteoclasts has no change in any parts of Cd. 5)These changes during IGF-I administration disappeared after IGF-I administration ended.