2010 Fiscal Year Final Research Report
Study of oral biofilm inhibitors from edible mushroom
| Project/Area Number |
21792165
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Iwate Biotechnology Research Center |
|---|
Principal Investigator |
YANO Akira Iwate Biotechnology Research Center, 生物資源研究部, 主席研究員 (50312286)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 予防歯科学 |
|---|
| Research Abstract |
We found the inhibitory effects of water-soluble extracts from edible mushroom, especially "Lentinula edodes", on sucrose-dependent biofilm formation by Streptococcus mutans . The extracts inhibit the water-soluble glucan synthesis by glucosyltransferase (GTF), expression of gtf genes and signaling genes related to the biofilm formation. We found the strong suppression of the quorum-sensing peptide gene, comC.
|
Research Products
(5 results)
