The mechanism of neural processing in the pontine nuclei that link the cerebrum to the cerebellum

2010 Fiscal Year Final Research Report

• Project/Area Number: 21800056
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: ISHIKAWA Taro 東京慈恵会医科大学, 医学部, 講師 (50547916)
• Project Period (FY): 2009 – 2010
• Keywords: 神経科学 / 生理学 / 薬理学 / 脳・神経

Research Abstract

The frequency of action potential firing of mossy-fiber projecting neurons in the pontine nuclei and the trigeminal nuclei were investigated. In the slice preparation, neither the pontine cells nor trigeminal cells showed high-frequency firings exceeding 500 Hz. This finding was in striking contrast to the high-frequency firing of mossy fibers that had been observed in anaesthetized animals in vivo. Therefore, it is suggested that, in the in vivo preparation, a mechanism that enhances cellular excitability might have a significant effect.

Research Products

• [Presentation] The origin of high-frequency firing pattern of the cerebellar mossy fibers (2011)
  • Author(s): Ishikawa T, Shimuta M, Li WB
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 20110914-17
• [Presentation] Multisensory signals in single cerebellar granule cells in vivo (2009)
  • Author(s): Ishikawa T, Shimuta M, Hausser M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-18
• [Presentation] Multisensory interactions in single cerebellar granule cells in vivo (2009)
  • Author(s): Shimuta M, Ishikawa T, Hausser M
  • Organizer: 第36回国際生理学会世界大会
  • Place of Presentation: 京都
  • Year and Date: 20090727-0801
• [Remarks]
  • URL: http://www.jikei.ac.jp/academic/course/08_yakuri.html