2010 Fiscal Year Final Research Report
Mechanism of hematopoietic impairment due to abnormal zinc metabolism
| Project/Area Number |
21800073
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Aichi Gakusen University |
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Principal Investigator |
KONOMI Aki Aichi Gakusen University, 家政学部, 講師 (40529658)
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| Research Collaborator |
YOKOI Katsuhiko 聖徳大学, 人間栄養学部, 教授 (10200883)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 亜鉛 / 造血 / 栄養 / 鉄不応性貧血 / エリスロポエチン |
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| Research Abstract |
Thirty 3-week-old male SD rats were assigned into 3 groups of 10 for the 4-week study. Difference between groups was statistically analyzed by Fisher's PLSD. P value less than 0.05 was considered significant. Plasma EPO concentration of zinc-deficient group was significantly decreased compared with control group, and pair-fed group was marginally decreased compared with control group (P=0.056). Kidney cortex EPO concentration was decreased in zinc-deficient group compared with pair-fed group. Kidney cortex EPO concentration in pair-fed group was higher than that of control group but the difference was not significant. No significant difference was observed in kidney medulla EPO concentration.
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