2010 Fiscal Year Final Research Report
Study for the mechanism linking intracellular amyloid precursor protein transport and lipid metabolism
| Project/Area Number |
21800075
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
URANO Yasuomi Doshisha University, 生命医科学部, 助教 (00546674)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 神経科学 / 脂質 / 痴呆 |
|---|
| Research Abstract |
A major pathological hallmark of Alzheimer's disease is the accumulation of Amyloid β(Aβ) in senile plaques. Aβ is generated from Amyloid precursor protein (APP). In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, caused the inhibition of intracellular APP trafficking from endoplasmic reticulum to Golgi, resulting the reduction of Aβ production. In addition, several candidate proteins, which were associated with APP in the presence of 24S-hydroxycholesterol, were indentified.
|
