2010 Fiscal Year Final Research Report
Computing with in vitro biochemical networks
| Project/Area Number |
21810004
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The University of Tokyo |
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Principal Investigator |
RONDELEZ Yannick The University of Tokyo, 生産技術研究所, 特任准教授 (10548770)
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| Project Period (FY) |
2009 – 2010
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| Keywords | DNAコンピュータ / DNA増幅反応 / 生化学ネットワーク |
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| Research Abstract |
Living organisms perform and control complex behaviors by using webs of chemical reactions organized in precise networks. This powerful system concept is at the very core of biology, but it is extremely difficult to rationally create such architectures in artificial, non-living systems. Here we use standard in vitro reactions from molecular biology to describe a toolkit for such a purpose. This approach is demonstrated by assembling an efficient chemical oscillator : we encode the wiring of the corresponding network in the sequence of small DNA templates, and obtain the predicted dynamics. Our results show that the cascading of simple modules opens the possibility to rationally and predictably implement complex behaviors in vitro.
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