2010 Fiscal Year Final Research Report

Methylated DNA binding protein MBD2/3 and its interacting proteins in Ciona intestinalis

Research Project

Project/Area Number	21810039
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	基礎ゲノム科学
Research Institution	Institute for Developmental Research, Aichi Human Service Center
Principal Investigator	SUZUKI Miho Institute for Developmental Research, Aichi Human Service Center, 発生障害学部, 研究員 (80548470)
Project Period (FY)	2009 – 2010
Keywords	メチル化CpG結合タンパク質 / Ciona intestinalis / メチル化DNA結合タンパク質 / DNAメチル化
Research Abstract	MBD2/3is highly expressed in early developmental stages of Ciona intestinalis. A knock down experiment depleting MBD2/3 protein in embryos caused severe developmental defects. The result indicated an important role of DNA methylation and methylated DNA binding protein in regulation of gene expression. Genome-wide distribution of MBD2/3 was limited to methylated gene body region. MBD2/3 possibly regulates expression of those more than 100gene targets.

(4 results)