2010 Fiscal Year Final Research Report
Methylated DNA binding protein MBD2/3 and its interacting proteins in Ciona intestinalis
| Project/Area Number |
21810039
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
SUZUKI Miho Institute for Developmental Research, Aichi Human Service Center, 発生障害学部, 研究員 (80548470)
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| Project Period (FY) |
2009 – 2010
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| Keywords | メチル化CpG結合タンパク質 / Ciona intestinalis / メチル化DNA結合タンパク質 / DNAメチル化 |
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| Research Abstract |
MBD2/3is highly expressed in early developmental stages of Ciona intestinalis. A knock down experiment depleting MBD2/3 protein in embryos caused severe developmental defects. The result indicated an important role of DNA methylation and methylated DNA binding protein in regulation of gene expression. Genome-wide distribution of MBD2/3 was limited to methylated gene body region. MBD2/3 possibly regulates expression of those more than 100gene targets.
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