Development of Efficient Synthetic Reactions Using Unique Properties of Water

2010 Fiscal Year Final Research Report

• Project/Area Number: 21850005
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Saitama University
• Principal Investigator: KINOSHITA Hidenori Saitama University, 理工学研究科, 助教 (20550007)
• Project Period (FY): 2009 – 2010
• Keywords: 有機化学 / 合成化学 / 遷移金属化学 / 水

Research Abstract

Water has unique properties which organic solvents do not have. The use of water for organic synthesis is not only environmentally friendly but also increases the efficiency of synthetic reactions. We therefore studied Pt(II)-catalyzed cyclization of alkynyl carbonyls in water. Particularly, our interest was focused on synthetic use of the π-Lewis acidity of Pt(II) catalysts in water. After exploring a wide range of conditions, we came to the realization that the desired cyclization did not proceed. However, during this study, we found that Pt(II)-catalyzed hydrative dimerization of alkynes to α, ss-unsaturated ketones.