2010 Fiscal Year Final Research Report
Synthetic Studies on Dearomatized Polycyclic Natural Products
| Project/Area Number |
21850012
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TAKIKAWA Hiroshi Tokyo Institute of Technology, 大学院・理工学研究科, 助教 (70550755)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 天然物合成 / 芳香族ポリケチド / 多環性化合物 / ニトリルオキシド / イソオキサゾール |
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| Research Abstract |
The type-II polyketide biosynthetic pathway produces a vast array of polycyclic natural products having a partially dearomatized structure, attracting the attention of the biochemical and synthetic communities. Based on the newly developed reactions with particular ortho-disubstituted nitrile oxide, we have developed viable methods for constructing the characteristic polycyclic skeleton and applied to the aromatic polyketide synthesis. Through these studies, the first total synthesis of seragakinone A, a novel pentacyclic marine antibiotic, was achieved.
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