2010 Fiscal Year Final Research Report
Construction of fluorescent ribonucleopeptide sensors for detecting signal transduction molecules.
| Project/Area Number |
21850018
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
FUKUDA Masatora Kyoto University, 理学部, 助教 (90526691)
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| Project Period (FY) |
2009 – 2010
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| Keywords | リボヌクレオペプチド / バイオセンサー / 生理活性物質 / 分子設計 / 分子進化工学 |
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| Research Abstract |
This research developed the methods of constructing fluorescent ribonucleopeptide (RNP) sensors for detecting signal transduction molecules. A covalently linked RNP sensor was designed by coupling an RNA subunit with a fluorophore -modified peptide subunit. The covalent linking strategy affords fluorescent RNP sensors for simultaneous detection of multiple ligands by monitoring each wavelength corresponding to the respective ligand.
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