2010 Fiscal Year Final Research Report
Development of Novel Chiral DMAP by Multicomponent Reactions
Project/Area Number |
21850020
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Synthetic chemistry
|
Research Institution | Okayama University |
Principal Investigator |
MANDAI Hiroki Okayama University, 大学院・自然科学研究科, 助教 (60534427)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 多成分連結反応 / 不斉求核触媒 / DMAP / 不斉触媒 / Petasis反応 / Ugi反応 |
Research Abstract |
Diastereoselective Petasis reaction of 4-(dimethylamino)-2-pyridinecarbaldehyde was examined by using chiral amine. Diastereoselectivity was slightly observed. On the other hand, the Ugi reactions of 4-(dimethylamino)-3-pyridinecarbaldehydes with DMAP-based aldehyde, α-amino acid, and isocyanide, affording desired chiral DMAP catalyst with high diastereoselectivities. The kinetic resolution of secondary alcohols using thus obtained chiral DMAP is also examined.
|