Wearable chemical sensor for noninvasive biomonitering

2010 Fiscal Year Final Research Report

• Project/Area Number: 21860025
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAHASHI Daishi Tokyo Medical and Dental University, 生体材料工学研究所, 特任助教 (20549943)
• Project Period (FY): 2009 – 2010
• Keywords: ウエアラブルセンサ / 酸素センサ / グルコースセンサ / 生体計測

Research Abstract

In fabrication process of an oxygen sensor, electrodes were formed on a polypropylene membrane by sputtering system. And then, a porous membrane with an electrolyte solution was encapsulated using a polyethylene membrane, obtaining the flexible oxygen sensor. In the evaluation of the sensor characteristics, the output current linearly correlated with the concentrations of dissolved oxygen and gaseous oxygen. The sensor was applied to rabbit's eye. As a result, the change of the output current with an inhalation of a high level oxygen gas was observed. Furthermore, a flexible glucose sensor was fabricated by immobilizing an enzyme onto the sensing region of the electrode.

Research Products

• [Journal Article] Soft contact lens biosensor for in-situ monitoring of tear glucose as non-invasive blood sugar assessment (2011)
  • Author(s): Chu MX, Miyajima K, Takahashi D, Arakawa T, Sano K, Sawada S, Kudo H, Iwasaki Y, Akiyoshi K, Mochizuki M, Mitsubayashi K
  • Journal Title: Talanta 83(3) Pages: 960-965
  • Peer Reviewed
• [Journal Article] Soft-MEMS glucose sensor with functional polymers (2010)
  • Author(s): Iguchi S, Chu MX, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
  • Journal Title: Journal of Photopolymer Science and Technology 23(2) Pages: 167-170
  • Peer Reviewed
• [Presentation] Contact lens type glucose sensor for continuous monitoring of tear sugar level (2010)
  • Author(s): Mitsubayashi K, Chu MX, , Hiranuma Y, Takahashi D, Arakawa T, Kudo H, Hiramatsu H
  • Organizer: Pacificchem 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 20101200
• [Presentation] 生体適合性ポリマーを用いたウエアラブルグルコースセンサに関する研究 (2010)
  • Author(s): 入江祐一, 矢野和義, 初明星, 平沼義貴, 平松秀夫, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
  • Organizer: 第22回SASインテリジェントシンポジウム
  • Place of Presentation: 平塚
  • Year and Date: 20101100
• [Presentation] 生体適合性ポリマーを用いたアルコール用フレキシブルセンサ (2010)
  • Author(s): 神白匠, 白井隆行, 矢野和義, 初明星, 平沼義貴, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
  • Organizer: 第22回SASインテリジェントシンポジウム
  • Place of Presentation: 平塚
  • Year and Date: 20101100
• [Presentation] Contact-lens type glucose sensor fabricated using Bionic-MEMS techniques for monitoring of tear sugar (2010)
  • Author(s): Mitsubayashi K, Chu MX, Takahashi D, Arakawa T, Kudo H
  • Organizer: The 61st Annual Meeting of the International Society of Electrochemistry
  • Place of Presentation: Nice, France
  • Year and Date: 20100926-20101001
• [Presentation] ソフトコンタクトレンズ型バイオセンサを用いた涙液グルコース連続計測に関する研究 (2010)
  • Author(s): 荒川貴博, 初明星, 高橋大志, 工藤寛之, 森本展行, 岩崎泰彦, 秋吉一成, 三林浩二
  • Organizer: 2010年・秋季<第71回>応用物理学会学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 20100914-20100917
• [Presentation] Development of a contact-lens shaped biosensor for in-vivo tear glucose monitoring (2010)
  • Author(s): Kudo H, Chu MX, Hiranuma Y, Takahashi D, Arakawa T, Mitsubayashi K
  • Organizer: The first Japan-China-Korea Joint Seminar on MEMS/NEMS 2010 for Green & Life Innovation
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 20100830-20100831
• [Presentation] A wearable glucose sensor for non-invasive biomonitoring on eye site (2010)
  • Author(s): Chu MX, Iguchi S, Takahashi D, Hiranuma Y, Arakawa T, Kudo H, Mitsubayashi K
  • Organizer: the 13^<th> international meeting of chemical sensors (IMCS-13)
  • Place of Presentation: Perth, Western Australia
  • Year and Date: 20100711-20100714
• [Presentation] Contact lens type biosensor fabricated using MEMS techniques on biocompatible polymers for continuous monitoring of tear glucose (2010)
  • Author(s): Chu MX, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
  • Organizer: 20th Anniversary World Congress on Biosensors, BIOSENSORS2010
  • Place of Presentation: Glasgow, UK
  • Year and Date: 20100526-20100528
• [Presentation] 涙液グルコースモニタリングのためのコンタクトレンズ型バイオセンサ (2010)
  • Author(s): 初明星, 高橋大志, 荒川貴博, 工藤寛之, 秋吉一成, 三林浩二, 森本展行, 岩崎泰彦
  • Organizer: 第85回日本医療機器学会大会
  • Place of Presentation: 福岡
  • Year and Date: 20100513-20100515
• [Presentation] 生体適合性ポリマー材料を用いたフレキシブルグルコースセンサ (2010)
  • Author(s): 平沼義貴, 初明星, 白井隆行, 高橋大志, 荒川貴博, 工藤寛之, 平松秀夫, 三林浩二
  • Organizer: 第57回応用物理学関係連合講演会
  • Place of Presentation: 平塚
  • Year and Date: 20100317-20100320
• [Presentation] Wearable Biosensor for Monitoring Tear Glucose on Rabbit Eye as Novel Device of Body Sensor Network (2009)
  • Author(s): Mitsubayashi K, Chu MX, Iguchi S, Takahashi D, Arakawa T, Kudo H
  • Organizer: The Fifth International Conference on Intelligent Sensors, Sensor Networks and Information Processing ISSNIP 2009
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 20091207-20091210
• [Presentation] A flexible sheet-type biosensor using biocompatible polymers (2009)
  • Author(s): Shirai T, Chu MX, Takahashi D, Arakawa T, Kudo H, Morimoto N, Yano K, Iwasaki Y, Akiyoshi K, Mitsubayashi K
  • Organizer: 8th Asian Conference on Chemical Sensors
  • Place of Presentation: Daegu, Korea
  • Year and Date: 20091114-20091117
• [Presentation] 生体適合性ポリマーを用いたウエアラブルグルコースセンサ (2009)
  • Author(s): 平沼義貴, 平松秀夫, 初明星, 白井隆行, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
  • Organizer: 第21回SASインテリジェントシンポジウム
  • Place of Presentation: 平塚(神奈川)
  • Year and Date: 20091100
• [Presentation] 涙液グルコース計測を目的としたコンタクトレンズ型バイオセンサ (2009)
  • Author(s): 初明星, 工藤寛之, 高橋大志, 荒川貴博, 秋吉一成, 三林浩二, 森本展行, 岩崎泰彦
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 札幌
  • Year and Date: 20090900