2010 Fiscal Year Final Research Report
a novel approach to create and characterize bone and bone marrow by the combination of tissue engineering and hematology
| Project/Area Number |
21860051
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kyoto University |
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Principal Investigator |
KOHARA Hiroshi Kyoto University, 医学研究科, 研究員 (40528733)
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| Project Period (FY) |
2009 – 2010
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| Keywords | バイオマテリアル / ゼラチンハイドロゲル / 徐放 / 神経ペプチド / 血管新生 / 骨形成 / 加齢変化 |
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| Research Abstract |
Angiogenesis was induced around the implanted site of gelatin hydrogels incorporating Substance P, a member of tachykinin family neuropeptides. In addition, accumulation of granulocytes, one of the circulating cells with angiogenic activities, around the implanted sites was observed. It is conceivable that the controlled release of SP efficiently induced the recruitment and the subsequent activation of granulocytes from the blood circulation into the site implanted, resulting in enhanced angiogenesis.
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