2010 Fiscal Year Final Research Report
AntiPeg11, as an essential antisense RNA : two differential role in mouse development.
| Project/Area Number |
21870011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ENDOU Daisuke Tokyo Medical and Dental University, 難治疾患研究所, 特任助教 (90516288)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 胎盤 / レトロトランスポゾン / microRNA / 発生 / ゲノムインプリンティング |
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| Research Abstract |
In this study, I demonstrated the two essential role of AntiPeg11/Rtl1as, non-coding antisense RNA of Peg11/Rtl1. MicroRNAs derived from AntiPeg11/Rtl1as repress the expression of their sense RNA, Peg11Rtl1 as a siRNA and down regulate the angiogenesis in the placenta to avoid the placentomegaly. Moreover, these microRNAs also regulate the expression of their target genes as microRNAs and contribute to the normal development, embryonic growth, and the formation of sternum.
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