2010 Fiscal Year Final Research Report
Analysis and synthesis of gene expression networks
| Project/Area Number |
21870017
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
EBISUYA Miki Kyoto University, 医学研究科, 助教 (00544933)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 遺伝子発現 / 網羅的解析 / 人工遺伝子回路 |
|---|
| Research Abstract |
In this work, we analyzed and synthesized gene expression networks. The aim of the synthesis project is to create "artificial cell-cell communications". We designed small gene networks using the modified Notch pathway, transcription factors and cultured cells. So far, we have successfully made a system by which the neighboring cells mutually regulate each other's gene expression. In the analysis project, on the other hand, we studied the mechanism and generality of the "transcriptional ripple effect". The obtained results have suggested that the ripple effect occurs only at specific genomic locations and/or under specific cellular conditions.
|
-
-
-
[Journal Article] The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.M2010
Author(s)
Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.
-
Journal Title
ol Biol Cell. 21
Pages: 2953-2965
Peer Reviewed
-
-
-
-
-
-
-
[Remarks] ホームページ等
