2010 Fiscal Year Final Research Report
Studies on stability of fission yeast heterochromatin and its regulators
| Project/Area Number |
21870024
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Shimane University |
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Principal Investigator |
KATO Hiroaki Shimane University, 医学部, 助教 (40548418)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ゲノム / 遺伝学 / エピジェネティクス / ヘテロクロマチン / 分裂酵母 |
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| Research Abstract |
In order to understand how the stability of heterochromatin is ensured, we first produced a mutant which abolishes Lys9 methylation of histone H3 at 36℃. Analysis of this mutant indicated that the abolishment of heterochromatin requires cell cycle progression. Next, we performed a genetic screen and identified transcriptional regulators as factors that are responsible for the stability of heterochromatin. These results suggest that DNA replication and transcription are risk factors for heterochromatin instability.
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