2010 Fiscal Year Final Research Report
Regulation of myosin II phosphorylation and dephosphorylation during apoptosis
| Project/Area Number |
21870029
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Ehime University |
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Principal Investigator |
IWASAKI Takahiro Ehime University, ベンチャー・ビジネス・ラボラトリー, 研究員 (40542999)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アポトーシス / ミオシン / 脱リン酸化 / カスパーゼ / ミオシンホスファターゼ |
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| Research Abstract |
It is known that myosin II is hyperphosphorylated in apoptotic cells. However, the regulation of myosin phosphatase (MP) in apoptosis is still unclear. In this study, we demonstrated that the activity of MP is reduced by caspae-3 mediated cleavage of myosin binding subunit. This result suggests that hyperphosphorylation of myosin II is induced by activation of myosin kinase and inactivation of MP during apoptosis.
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