2010 Fiscal Year Final Research Report
Regulation of the balance between proliferation and differentiation of neural progenitors in different histogenesis of brain.
| Project/Area Number |
21870030
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
HATAKEYAMA Jun Kumamoto University, 発生医学研究所, 助教 (90404350)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経幹細胞 / 増殖 / 分化 / 脳 / 領域性 / Notch |
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| Research Abstract |
Development of the central nervous system (CNS) requires an exquisite balance between proliferation and differentiation of the neural progenitors. The balance must be important for forming regional histogenesis. However the mechanisms remain poorly understood. Our results indicated that the apical endfeet of nascent neurons are important for regulating the balance. We suggest that the apical endfeet of neurons serve as a switch for neurogenesis, thereby regulating histogenesis of the CNS tissue.
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