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2010 Fiscal Year Final Research Report

Analysis on a possible link between piRNA biogenesis and microtubule organization

Research Project

  • PDF
Project/Area Number 21870032
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Genetics/Genome dynamics
Research InstitutionKeio University

Principal Investigator

SATO Kaoru  Keio University, 医学部, 助教 (20548507)

Project Period (FY) 2009 – 2010
KeywordsRNAサイレンシング / 微小管 / 中心体 / ショウジョウバエ / 生殖細胞 / 細胞分裂
Research Abstract

A research goal of this study is to clarify a molecular function of the maelstrom (mael) gene, which is involved in RNA silencing, in microtubule and centrosome organization. By the immunoprecipitation method using an anti-Mael monoclonal antibody, I identified γTubulin protein as novel Mael associating factor. In addition, abnormality we observed an abnormal localization of γTubulin in the mael mutant egg chambers. These results suggest that mael plays an essential role for egg development via consistently possibly regulating proper microtubule and centrosome organization by physically associating with peri-centriolar proteins during Drosophila oogenesis.

  • Research Products

    (5 results)

All 2011 2010 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Maelstrom interacts with protein components of MTOC and is required for proper segregation of egg chambers in Drosophila ovary2011

    • Author(s)
      佐藤薫
    • Organizer
      Keystone Symposia -Mechanism and Biology of Silencing-
    • Place of Presentation
      Monterey, California
    • Year and Date
      20110320-20110325
  • [Presentation] ショウジョウバエ卵巣におけるpiRNA生合成関連遺伝子maelstromの機能解析2010

    • Author(s)
      佐藤薫
    • Organizer
      第12回RNA 学会年会
    • Place of Presentation
      一橋記念講堂
    • Year and Date
      20100727-20100729
  • [Presentation] A possible link between piRNA biogenesis and microtubule organization in Drosophila ovaries2010

    • Author(s)
      佐藤薫
    • Organizer
      19th CDB Meeting: RNA Sciences in Cell and Developmental Biology
    • Place of Presentation
      Kobe, RIKEN CDB
    • Year and Date
      20100510-20100512
  • [Presentation] A possible link between piRNA biogenesis and microtubule organization in Drosophila ovaries2010

    • Author(s)
      佐藤薫
    • Organizer
      2010 Keystone symposia・RNA silencing : Mechanism, biology and Application
    • Place of Presentation
      Keystone, Colorado, USA
    • Year and Date
      20100114-20100119
  • [Remarks] ホームページ等

    • URL

      http://web.sc.itc.keio.ac.jp/dmb/sindex.html

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Published: 2012-01-26   Modified: 2016-04-21  

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